Ten years after the explosion of Flight 180, nine years after the pile-up on Route 23, and four years after the derailment of the Devil's Flight roller coaster, Nick O'Bannon (Bobby Campo) has a premonition of a racecar crash at the McKinley Speedway race track which sends debris flying into the audience, crushing several spectators and resulting in the stadium collapsing, which kills almost everyone in the 180 section. In a quick second, Nick manages to convince his girlfriend Lori Milligan (Shantel VanSanten), and friends Hunt Wynorski (Nick Zano) and Janet Cunningham (Haley Webb) to leave the stadium. They are followed out by others who are angry when the group pushes past them to escape, including mother Samantha Lane (Krista Allen), mechanic Andy Kewzer (Andrew Fiscella) and his girlfriend Nadia Monroy (Stephanie Honoré), racist Carter Daniels (Justin Welborn), and security guard George Lanter (Mykelti Williamson). The catastrophe Nick had seen occurs and kills several people, including Carter's wife, Cynthia (Lara Grice). A tire flies out of the race track seconds later and decapitates Nadia.
After a memorial service at McKinley Speedway, Carter is blown up with his tow truck and Samantha is killed by a flying rock propelled by a lawnmower, which goes through her eye. Before their deaths, Nick had seen how they would die. After hearing about Carter and Samantha's deaths on the news, Nick and Lori begin doing research, and learn about the disasters that occurred during the three previous incidents. First there was the Flight 180 explosion, then the Route 23 pile-up, and then the Devil's Flight derailment. The survivors in all three disasters began dying in a series of improbable accidents shortly afterward in the order they were meant to die originally. While Hunt and Janet refuse to believe them, Nick and Lori manage to convince George that Death is after them and the trio begin trying to warn the other survivors. The next to die is Andy, who is diced through a chain link fence by a CO2 tank. Hunt later goes to the pool and his intestines are sucked out violently by the drain. Lori and George are able to save Janet from drowning in a car wash and think they have defeated Death, but Jonathan Grove (Jackson Walker), another survivor, is crushed when a ceiling collapses.
Nick has another premonition where George is hit by an ambulance and Janet, Lori, and himself are killed by an explosion in a mall movie theater. When Nick wakes up from the premonition, George gets hit by the ambulance, leaving Nick to save Janet and Lori on his own. He succeeds in extinguishing the fire that would have caused the initial explosion.
Weeks later, the trio, thinking they have conquered Death's plan, celebrate surviving in a cafe. Nick notices a loose leg on a scaffold outside the cafe, and he tells a construction worker to fix it up. Once inside he drifts off into thought after seeing omens around him, and realizes that his premonitions and signs, along with all the disasters and deaths that had occurred since the speedway incident, are red herrings from Death used to manipulate them into where and when it would really come for them. Just as Nick realizes this, the scaffold falls, and in order to avoid it, a truck swerves, and crashes through the cafe window, crushing Janet, Lori, and Nick, thus leaving no survivors of McKinley Speedway.
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